2',3'-cGAMP

2',3'-cGAMP

• CAS Number: 1441190-66-4
• UNSPSC Description: 2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm[1].
• Target Antigen: Endogenous Metabolite; IFNAR; STING
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/2-3-cgamp.html
• Purity: 99.95
• Solubility: H2O : ≥ 50 mg/mL
• Smiles: OC1([H])[C@](OP(O)(OC[C@](O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@@H]4O)([H])[C@@]4([H])O5)=O)([H])[C@H](N6C(NC(N)=NC7=O)=C7N=C6)O[C@]1([H])COP5(O)=O
• Molecular Weight: 674.41
• References & Citations: [1]Zhang X, et al. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol Cell. 2013 Jul 25;51(2):226-35.ACS Appl Bio Mater. 2024 Sep 17.|Acta Materia Medica . 2023 Jun 17.|Bioact Mater. 2024 Sep 6:42:345-365.|Cell Commun Signal. 2023 Sep 28;21(1):264.|J Immunol. 2021 Apr 15;206(8):1844-1857.|J Virol. 2023 Oct 16:e0127923.|Res Sq. 2024 May 30.|Adv Mater. 2024 Mar 24:e2401384.|bioRxiv. 2024 Apr 12.|Cancers (Basel). 2024 Oct 30;16(21):3657.|Cell Rep. 2023 Feb 28;42(3):112145.|Fundamental Research. 2023 May 11.|Neuron. 2022 Nov 4;S0896-6273(22)00961-8.|Protein Cell. 2021 Oct 22;1-21.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported