3'2'-cGAMP

• Description :

  3'2'-cGAMP (c[A (2',5') pG (3',5') p]) is a cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) isomer. 3'2'-cGAMP exhibits high selectivity for Drosophila STING (dSTING), activating the dSTING-NF-κB signaling pathway, inducing the expression of Sting-regulated genes (Srg) and conferring a potent antiviral state in vivo. 3'2'-cGAMP is resistant to cleavage by viral poxins. 3'2'-cGAMP can be used for the study of viral infections[1].

• CAS Number :

  [1615704-64-7]

• Product Name Alternative :

  C[A (2',5') pG (3',5') p]

• UNSPSC :

  12352005

• Target :

  NF-κB; STING

• Related Pathways :

  Immunology/Inflammation; NF-κB

• Field of Research :

  Infection

• Smiles :

  O=C1C(N=CN2[C@H]3[C@H](O)[C@H](OP4(O)=O)[C@@H](COP(O)(O[C@@H]5[C@H](O)[C@@H](CO4)O[C@H]5N(C=N6)C7=C6C(N)=NC=N7)=O)O3)=C2N=C(N)N1

• Molecular Formula :

  C20H24N10O13P2

• Molecular Weight :

  674.41

• References & Citations :

  [1]Slavik KM, et al. cGAS-like receptors sense RNA and control 3'2'-cGAMP signalling in Drosophila. Nature. 2021 Sep;597 (7874) :109-113.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported