2'2'-cGAMP (disodium)

CAT: 0804-HY-137709ASize: 500 µgDry Ice: NoHazardous: No
CAT#:0804-HY-137709ASize:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
2'2'-cGAMP disodium, a synthetic CDN, binds STING in the immune response, inducing IFN-β. 2'2'-cGAMP disodium binds weaker binding to STING than 2'3'-cGAMP (HY-100564) but stronger than other CDNs[1].
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite; IFNAR; STING
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Purity
99.6
Smiles
O[C@H]1[C@](O[P](OC[C@@]([C@H]2O)([H])O[C@](N3C4=NC=NC(N)=C4N=C3)([H])[C@]2([H])O5)(O[Na])=O)([H])[C@](O[C@]1([H])CO[P]5(O[Na])=O)([H])N6C(NC(N)=NC7=O)=C7N=C6
Molecular Formula
C20H22N10Na2O13P2
Molecular Weight
718.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhang X, et al. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol Cell. 2013;51 (2) :226-235.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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