CGAMP

CAT: 0804-HY-12512-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-12512-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CGAMP (Cyclic GMP-AMP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators[1][2][3][4].
CAS Number
[849214-04-6]
Product Name Alternative
Cyclic GMP-AMP; 3',3'-cGAMP
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
STING
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cGAMP.html
Purity
99.22
Solubility
H2O : 180 mg/mL (ultrasonic)
Smiles
O=P(O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1COP4(O)=O)(O)OC[C@@H]5[C@@H](O4)[C@@H](O)[C@H](N6C=NC7=C6N=C(N)NC7=O)O5
Molecular Formula
C20H24N10O13P2
Molecular Weight
674.41
Precautions
H302, H315, H319, H335
References & Citations
[1]Wu J, et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 2013 Feb 15;339 (6121) :826-30.|[2]Skrnjug I, et al. Cyclic GMP-AMP displays mucosal adjuvant activity in mice. PLoS One. 2014 Oct 8;9 (10) :e110150.|[3]Liu Y, et al. Activated STING in a vascular and pulmonary syndrome. N Engl J Med. 2014 Aug 7;371 (6) :507-18.|[4]Ablasser A, et al. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature. 2013 Nov 28;503 (7477) :530-4.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
ACS Nano. 2025 Mar 4;19 (8) :8277-8293.|Adv Sci (Weinh) . 2025 Mar 26:e2502750.|Biochem Pharmacol. 2023 Jul:213:115618.|Biomaterials. 2023 Jun:297:122104.|Cancer Immunol Res. 2025 Nov 11.|Cell Death Differ. 2025 Jun;32 (6) :1167-1179.|Cell Rep. 2023 Apr 5;42 (4) :112328.|Chem Eng J. 2022: 140190.|Chin Herb Med. 2024 Apr 30;16 (3) :422-434.|J Nanobiotechnology. 2022 Jan 6;20 (1) :23.|Nat Commun. 2024 Dec 4;15 (1) :10543.|Nat Commun. 2024 Jul 18;15 (1) :6053.|Nat Commun. 2024 Jul 23;15 (1) :6193.|Nat Commun. 2025 May 23;16 (1) :4793.|Sci China Life Sci. 2024 Dec;67 (12) :2664-2677.|Signal Transduct Target Ther. 2025 Oct 1;10 (1) :321.|bioRxiv. 2020 Jul.|Int Immunopharmacol. 2025 Aug 6:164:115310.|Patent. US20210017607A1.

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