cGAMP

• Product Name Alternative:

  Cyclic GMP-AMP; 3',3'-cGAMP

• UNSPSC Description:

  cGAMP (Cyclic GMP-AMPP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators[1][2][3][4].

• Target Antigen:

  STING

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/cGAMP.html

• Purity:

  99.22

• Solubility:

  H2O : 180 mg/mL (ultrasonic)

• Smiles:

  O=P(O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1COP4(O)=O)(O)OC[C@@H]5[C@@H](O4)[C@@H](O)[C@H](N6C=NC7=C6N=C(N)NC7=O)O5

• Molecular Weight:

  674.41

• References & Citations:

  [1]Wu J, et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 2013 Feb 15;339(6121):826-30.|[2]Skrnjug I, et al. Cyclic GMP-AMP displays mucosal adjuvant activity in mice. PLoS One. 2014 Oct 8;9(10):e110150.|[3]Liu Y, et al. Activated STING in a vascular and pulmonary syndrome. N Engl J Med. 2014 Aug 7;371(6):507-18.|[4]Ablasser A, et al. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature. 2013 Nov 28;503(7477):530-4.Biochem Pharmacol. 2023 May 19;213:115618.|Biomaterials. 2023 Mar 31, 122104.|Cell Rep. 2023 Apr 5;42(4):112328.|Chem Eng J. 2022: 140190.|Chin Herb Med. 2024 Jul.|J Nanobiotechnology. 2022 Jan 6;20(1):23.|Nat Commun. 2024 Jul 18;15(1):6053.|Nat Commun. 2024 Jul 23;15(1):6193.|Sci China Life Sci. 2024 Aug 22.|bioRxiv. 2020 Jul.|Patent. US20210017607A1.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  849214-04-6