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CGAMP (disodium)

CAT: 0804-HY-110385-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-110385-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CGAMP (Cyclic GMP-AMP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators[1][2][3][4].
CAS Number
2407516-83-8
Product Name Alternative
Cyclic GMP-AMP (disodium) ; 3',3'-cGAMP (disodium)
UNSPSC
12352005
Target
Endogenous Metabolite; STING
Type
Natural Products
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cgamp-disodium.html
Purity
98.47
Solubility
H2O : 180 mg/mL (ultrasonic; warming)
Smiles
[H][C@@]12COP(O[C@]3([C@H]([C@H](N4C=NC5=C(N=CN=C45)N)O[C@@]3(COP(O[C@]1([C@H]([C@H](N6C=NC7=C6N=C(N)NC7=O)O2)O)[H])(O[Na])=O)[H])O)[H])(O[Na])=O
Molecular Formula
C20H22N10Na2O13P2
Molecular Weight
718.37
References & Citations
[1]Wu J, et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 2013 Feb 15;339 (6121) :826-30.|[2]Skrnjug I, et al. Cyclic GMP-AMP displays mucosal adjuvant activity in mice. PLoS One. 2014 Oct 8;9 (10) :e110150.|[3]Ablasser A, et al. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature. 2013 Nov 28;503 (7477) :530-4.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite
Citation 01
BioRxiv. 2020 Jul.|Int Immunopharmacol. 2025 Aug 6:164:115310.|Patent. US20210017607A1.|ACS Nano. 2025 Mar 4;19 (8) :8277-8293.|Adv Sci (Weinh) . 2025 Mar 26:e2502750.|Biochem Pharmacol. 2023 Jul:213:115618.|Biomaterials. 2023 Jun:297:122104.|Cancer Immunol Res. 2025 Nov 11.|Cell Death Differ. 2025 Jun;32 (6) :1167-1179.|Cell Rep. 2023 Apr 5;42 (4) :112328.|Chem Eng J. 2022: 140190.|Chin Herb Med. 2024 Apr 30;16 (3) :422-434.|J Nanobiotechnology. 2022 Jan 6;20 (1) :23.|Nat Commun. 2024 Dec 4;15 (1) :10543.|Nat Commun. 2024 Jul 18;15 (1) :6053.|Nat Commun. 2024 Jul 23;15 (1) :6193.|Nat Commun. 2025 May 23;16 (1) :4793.|Sci China Life Sci. 2024 Dec;67 (12) :2664-2677.|Signal Transduct Target Ther. 2025 Oct 1;10 (1) :321.

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