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(R) -Hydroxychloroquine

CAT: 0804-HY-B1370B-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1370B-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(R) -Hydroxychloroquine is the enantiomer of Hydroxychloroquine[1]. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro[2][3][4].
CAS Number
137433-23-9
Product Name Alternative
(R) -HCQ
UNSPSC
12352005
Hazard Statement
H302-H317
Target
Autophagy; Parasite; SARS-CoV; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Anti-infection; Autophagy; Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/r-hydroxychloroquine.html
Solubility
10 mM in DMSO
Smiles
CCN(CCO)CCC[C@H](NC1=CC=NC2=CC(Cl)=CC=C12)C
Molecular Formula
C18H26ClN3O
Molecular Weight
335.87
Precautions
P261-P264-P270-P272-P280-P302+P352-P330-P363-P501
References & Citations
[1]Cardoso CD, et al. Enantioselective analysis of the metabolites of hydroxychloroquine and application to an in vitro metabolic study. J Pharm Biomed Anal. 2005 Apr 1;37 (4) :703-8.|[2]Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4 (1) :6.|[3]. Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85 (3) :429-40.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Plasmodium; TLR7; TLR9

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