(S) -Hydroxychloroquine

• Description :

  (S) -Hydroxychloroquine ((S) -HCQ) is the enantiomer of Hydroxychloroquine[1]. Hydroxychloroquine, a synthetic antimalarial agent, inhibits Toll-like receptor 7/9 (TLR7/9) signaling, and shows efficiently inhibits SARS-CoV-2 infection in vitro[2][3][4].

• CAS Number :

  [137433-24-0]

• Product Name Alternative :

  (S) -HCQ

• UNSPSC :

  12352005

• Hazard Statement :

  H315-H319-H320

• Target :

  Autophagy; Parasite; SARS-CoV; Toll-like Receptor (TLR)

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Autophagy; Immunology/Inflammation

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/s-hydroxychloroquine.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CCN(CCO)CCC[C@@H](NC1=CC=NC2=CC(Cl)=CC=C12)C

• Molecular Formula :

  C18H26ClN3O

• Molecular Weight :

  335.87

• Precautions :

  P264-P280-P302+P352-P305+P351+P338-P362

• References & Citations :

  [1]Cardoso CD, et al. Enantioselective analysis of the metabolites of hydroxychloroquine and application to an in vitro metabolic study. J Pharm Biomed Anal. 2005 Apr 1;37 (4) :703-8.|[2]Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4 (1) :6.|[3]Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85 (3) :429-40.|[4]Yao X, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) . Clin Infect Dis. 2020 Mar 9. pii: ciaa237.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  Plasmodium; TLR7; TLR9