Hydroxychloroquine-d5

CAT: 0804-HY-W031727S1Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-W031727S1Size:1 mg
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Description
Hydroxychloroquine-d5 is the deuterium labeled Hydroxychloroquine[1]. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro[2][3][4].
UNSPSC
12352005
Target
Autophagy; Parasite; SARS-CoV; Toll-like Receptor (TLR)
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Autophagy; Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
CC(NC1=CC=NC2=C1C=CC(Cl)=C2)CCCN(CCO)C([2H])(C([2H])([2H])[2H])[2H].OC(C(O)=O)=O.OC(C(O)=O)=O
Molecular Formula
C22H25D5ClN3O9
Molecular Weight
520.97
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4 (1) :6.|[3]Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar85 (3) :429-40.|[4]Yao X, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) . Clin Infect Dis. 2020 Mar 9. pii: ciaa237.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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