Hydroxychloroquine-d5

• Description :

  Hydroxychloroquine-d5 is the deuterium labeled Hydroxychloroquine[1]. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro[2][3][4].

• UNSPSC :

  12352005

• Target :

  Autophagy; Parasite; SARS-CoV; Toll-like Receptor (TLR)

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Anti-infection; Autophagy; Immunology/Inflammation

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Cancer

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(NC1=CC=NC2=C1C=CC(Cl)=C2)CCCN(CCO)C([2H])(C([2H])([2H])[2H])[2H].OC(C(O)=O)=O.OC(C(O)=O)=O

• Molecular Formula :

  C22H25D5ClN3O9

• Molecular Weight :

  520.97

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4 (1) :6.|[3]Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar85 (3) :429-40.|[4]Yao X, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) . Clin Infect Dis. 2020 Mar 9. pii: ciaa237.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported