Hydroxychloroquine-d5

• Description:

  Hydroxychloroquine-d5 is the deuterium labeled Hydroxychloroquine[1]. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro[2][3][4].

• UNSPSC:

  12352005

• Target:

  Autophagy; Parasite; SARS-CoV; Toll-like Receptor (TLR)

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Anti-infection; Autophagy; Immunology/Inflammation

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Cancer

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(NC1=CC=NC2=C1C=CC(Cl)=C2)CCCN(CCO)C([2H])(C([2H])([2H])[2H])[2H].OC(C(O)=O)=O.OC(C(O)=O)=O

• Molecular Formula:

  C22H25D5ClN3O9

• Molecular Weight:

  520.97

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4 (1) :6.|[3]Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar85 (3) :429-40.|[4]Yao X, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) . Clin Infect Dis. 2020 Mar 9. pii: ciaa237.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported