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Hydroxychloroquine-d4 (sulfate)

CAT: 0804-HY-B1370SSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B1370SSize:1 Each
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Description
Hydroxychloroquine-d4 (sulfate) is the deuterium labeled Hydroxychloroquine sulfate. Hydroxychloroquine sulfate (HCQ sulfate) is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine sulfate is efficiently inhibits SARS-CoV-2 infection in vitro[1][2][3].
CAS Number
1854126-45-6
Product Name Alternative
HCQ-d4 (sulfate)
UNSPSC
12352005
Hazard Statement
H225-H319
Target
Autophagy; Isotope-Labeled Compounds; Parasite; SARS-CoV; Toll-like Receptor (TLR)
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Autophagy; Immunology/Inflammation; Others
Field of Research
Cancer; Infection
Solubility
10 mM in DMSO
Smiles
O=S(O)(O)=O.OC([2H])([2H])C([2H])([2H])N(CC)CCCC(C)NC1=CC=NC2=C1C=CC(Cl)=C2
Molecular Formula
C18H24D4ClN3O5S
Molecular Weight
437.97
Precautions
P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P370+P378-P403+P235-P501
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4 (1) :6.|[3]Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85 (3) :429-40.|[4]Yao X, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) . Clin Infect Dis. 2020 Mar 9. pii: ciaa237.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
Plasmodium

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