Hydroxychloroquine Impurity E

• Description :

  Hydroxychloroquine Impurity E is the impurity of Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro[1][2][3].

• Product Name Alternative :

  4-[ (7-Chloro-4-quinolinyl) amino]-1-pentanol

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  SARS-CoV; Toll-like Receptor (TLR)

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Immunology/Inflammation

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/hydroxychloroquine-impurity-e.html

• Purity :

  99.83

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(NC1=CC=NC2=CC(Cl)=CC=C12)CCCO

• Molecular Formula :

  C14H17ClN2O

• Molecular Weight :

  264.75

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4 (1) :6.|[2]Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85 (3) :429-40.|[3]Yao X, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) . Clin Infect Dis. 2020 Mar 9. pii: ciaa237.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [10500-64-8]