Hydroxychloroquine Impurity E

• UNSPSC Description:

  Hydroxychloroquine Impurity E is the impurity of Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro[1][2][3].

• Target Antigen:

  SARS-CoV; Toll-like Receptor (TLR)

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Immunology/Inflammation

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/hydroxychloroquine-impurity-e.html

• Purity:

  99.83

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(NC1=CC=NC2=CC(Cl)=CC=C12)CCCO

• Molecular Weight:

  264.75

• References & Citations:

  [1]Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4(1):6.|[2]Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40.|[3]Yao X, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020 Mar 9. pii: ciaa237.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Clinical Information:

  No Development Reported

• CAS Number:

  10500-64-8