Hydroxychloroquine Impurity E

CAT: 0804-HY-131262Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-131262Size:100 mg
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Description
Hydroxychloroquine Impurity E is the impurity of Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro[1][2][3].
CAS Number
[10500-64-8]
Product Name Alternative
4-[ (7-Chloro-4-quinolinyl) amino]-1-pentanol
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
SARS-CoV; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Anti-infection; Immunology/Inflammation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/hydroxychloroquine-impurity-e.html
Purity
99.83
Solubility
10 mM in DMSO
Smiles
CC(NC1=CC=NC2=CC(Cl)=CC=C12)CCCO
Molecular Formula
C14H17ClN2O
Molecular Weight
264.75
Precautions
H302, H315, H319, H335
References & Citations
[1]Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4 (1) :6.|[2]Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85 (3) :429-40.|[3]Yao X, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) . Clin Infect Dis. 2020 Mar 9. pii: ciaa237.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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MBS5815998Hydroxychloroquine Impurity E
MBS5815999Hydroxychloroquine Impurity F
RM-H042442-01Hydroxychloroquine Sulfate Impurity 42
RM-H042415-01Hydroxychloroquine Sulfate Impurity 15
RM-H042449-01Hydroxychloroquine Sulfate Impurity 49
RM-H042458-01Hydroxychloroquine Sulfate Impurity 58
RM-H042470-01Hydroxychloroquine sulfate Impurity 70
RM-H042465-01Hydroxychloroquine sulfate Impurity 65
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