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HDAC8-IN-12

CAT: 0804-HY-161954Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161954Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC8-IN-12 (compound 5k) is a non-hydroxamic acid, selective inhibitor of HDAC8 (IC50: 0.12 nM) and a potent inhibitor of breast cancer. HDAC8-IN-12 triggers anti-tumor immunity by activating T cells, increasing the proportion of M1 macrophages and decreasing the proportion of M2 macrophages. HDAC8-IN-12 (50 mg/kg) exerts tumor suppressive effects in an orthotopic mouse model of breast cancer[1].
CAS Number
3028095-13-5
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac8-in-12.html
Smiles
CN(/C1=C\C2=CC=C(C(OC)=C2)/C=C/C(NO)=O)C(CNC1=O)=O
Molecular Formula
C16H17N3O5
Molecular Weight
331.32
References & Citations
[1]Natural Derivatives of Selective HDAC8 Inhibitors with Potent in Vivo Antitumor Efficacy against Breast Cancer
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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