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HDAC8-IN-12

CAT: 0013-GTR19238986-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19238986-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC8-IN-12 (compound 5k) is a potent and selective non-hydroxamic acid HDAC8 inhibitor (IC50 = 0.12 nM) . It demonstrates anti-breast cancer activity in vitro and in an orthotopic mouse model, where it modulates the tumor immune microenvironment by activating T cells and shifting macrophage polarization from M2 to M1.
CAS Number
3028095-13-5
Field of Research
Epigenetics & Chromatin, Molecular Biology
Smiles
O=C (C=CC1=CC=C (C=C1OC) C=C2C (=O) NCC (=O) N2C) NO
Molecular Formula
C16H17N3O5
Molecular Weight
331.32
Storage Conditions
-20°C
Notes
For research use only.

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