HDAC8-IN-2

HDAC8-IN-2

• CAS Number: 2824131-20-4
• UNSPSC Description: HDAC8-IN-2 (compound 5o) is a potent HDAC8 inhibitor, with IC50 values of 0.27 and 0.32 μM for smHDAC8 (Schistosoma mansoni histone deacetylase 8) and hHDAC8, respectively. HDAC8-IN-2 shows significant killing of the schistosome larvae. HDAC8-IN-2 markedly impairs egg laying of adult worm pairs[1].
• Target Antigen: HDAC; Parasite
• Type: Reference compound
• Related Pathways: Anti-infection;Cell Cycle/DNA Damage;Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/hdac8-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: COC1=C(C=C(C=C1)C(NO)=O)NC(C2=C3OC4=C(C3=CC=C2)C=CC=C4)=O
• Molecular Weight: 376.36
• References & Citations: [1]Ghazy E, et al. Synthesis, structure-activity relationships, cocrystallization and cellular characterization of novel smHDAC8 inhibitors for the treatment of schistosomiasis. Eur J Med Chem. 2021 Dec 5;225:113745.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported