HDAC8-IN-4

• Description:

  HDAC8-IN-4 is a selective inhibitor of HDAC8. HDAC8-IN-4 inhibits HDAC8 and HDAC3 with IC50s of 0.15 and 12 μM[1].

• UNSPSC:

  12352005

• Target:

  HDAC

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/hdac8-in-4.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C (C1=CC=CC (C2=CSC (CSC3=CC=CC=C3) =N2) =C1) NO

• Molecular Formula:

  C17H14N2O2S2

• Molecular Weight:

  342.44

• References & Citations:

  [1]Suzuki T, et al. Design, synthesis, and biological activity of NCC149 derivatives as histone deacetylase 8-selective inhibitors. ChemMedChem. 2014 Mar;9 (3) :657-64.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  HDAC3; HDAC8

• CAS Number:

  1600528-05-9