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HDAC8-IN-3

CAT: 0804-HY-147934Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147934Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC8-IN-3 (compound P19) is a potent HDAC8 inhibitor with IC50 value of 9.3 μM and produces thermal stabilization. HDAC8-IN-3 has cytotoxicity and induces apoptosis in leukemic cell lines[1].
CAS Number
2432825-93-7
UNSPSC
12352005
Target
Apoptosis; HDAC
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac8-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=NC2=CC=CC=C2S1)CN(C/3=O)C(SC3=C\C4=NC=CC=C4)=O
Molecular Formula
C18H12N4O3S2
Molecular Weight
396.44
References & Citations
[1]Upadhyay N, et al. Discovery of novel N-substituted thiazolidinediones (TZDs) as HDAC8 inhibitors: in-silico studies, synthesis, and biological evaluation. Bioorg Chem. 2020 Jul;100:103934.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC2; HDAC3; HDAC4; HDAC5; HDAC6; HDAC8

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