HDAC8-IN-3

• UNSPSC Description:

  HDAC8-IN-3 (compound P19) is a potent HDAC8 inhibitor with IC50 value of 9.3 μM and produces thermal stabilization. HDAC8-IN-3 has cytotoxicity and induces apoptosis in leukemic cell lines[1].

• Target Antigen:

  Apoptosis; HDAC

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Cell Cycle/DNA Damage;Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/hdac8-in-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NC1=NC2=CC=CC=C2S1)CN(C/3=O)C(SC3=C\C4=NC=CC=C4)=O

• Molecular Weight:

  396.44

• References & Citations:

  [1]Upadhyay N, et al. Discovery of novel N-substituted thiazolidinediones (TZDs) as HDAC8 inhibitors: in-silico studies, synthesis, and biological evaluation. Bioorg Chem. 2020 Jul;100:103934.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2432825-93-7