HDAC8-IN-3

• Description :

  HDAC8-IN-3 (compound P19) is a potent HDAC8 inhibitor with IC50 value of 9.3 μM and produces thermal stabilization. HDAC8-IN-3 has cytotoxicity and induces apoptosis in leukemic cell lines[1].

• CAS Number :

  [2432825-93-7]

• UNSPSC :

  12352005

• Target :

  Apoptosis; HDAC

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage; Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/hdac8-in-3.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NC1=NC2=CC=CC=C2S1)CN(C/3=O)C(SC3=C\C4=NC=CC=C4)=O

• Molecular Formula :

  C18H12N4O3S2

• Molecular Weight :

  396.44

• References & Citations :

  [1]Upadhyay N, et al. Discovery of novel N-substituted thiazolidinediones (TZDs) as HDAC8 inhibitors: in-silico studies, synthesis, and biological evaluation. Bioorg Chem. 2020 Jul;100:103934.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HDAC1; HDAC2; HDAC3; HDAC4; HDAC5; HDAC6; HDAC8