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Nav1.8-IN-7

CAT: 0804-HY-160588Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-160588Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nav1.8-IN-7 (Example 116) is a selective Nav1.8 inhibitor. Nav1.8-IN-7 shows an inhibition of >50% with 100 nM for Nav1.8. Nav1.8-IN-7 inhibits hERG with an IC50 of 15.6 μM. Nav1.8-IN-7 has the potential for pain research[1].
CAS Number
2761181-58-0
UNSPSC
12352005
Target
Potassium Channel; Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nav1-8-in-7.html
Solubility
10 mM in DMSO
Smiles
OC[C@@H](O)COC1=CC(NC(C(C=C(C(C(F)(F)F)=C2)Cl)=C2OC3=C(C=C(C=C3)F)C)=O)=CN=N1
Molecular Formula
C22H18ClF4N3O5
Molecular Weight
515.84
References & Citations
[1]Junfeng Ren, et al. A benzylamine or benzyl alcohol derivative and its use. CN114031518A.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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