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Nav1.8-IN-20

CAT: 0804-HY-174845Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174845Size:1 Each
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Description
Nav1.8-IN-20 (Compound I) is an orally active and potent voltage-gated sodium channel Nav1.8 inhibitor with an IC50 value of 14 nM. Nav1.8-IN-20 blocks the generation and conduction of action potentials in peripheral nociceptive neurons, exerting analgesic effects. Nav1.8-IN-20 is promising for research of various pain types such as acute pain, chronic pain, inflammatory pain, and neuropathic pain[1].
CAS Number
3024470-62-7
UNSPSC
12352005
Target
Sodium Channel
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Smiles
ClC1=C(Cl)C=C(OC2=CC=C(OC(F)(F)F)C=C2)C(C(NC3=C[N+]([O-])=CN=C3)=O)=C1
Molecular Formula
C18H10Cl2F3N3O4
Molecular Weight
460.19
References & Citations
[1]Zhang XJ, et al. Nav1.8 inhibitor compound, salt thereof, polymorph thereof, and use thereof. WO2025124502A1. 2025-06-19.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nav1.8

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