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Nav1.8-IN-20

CAT: 0931-T210748-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T210748-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3024470-62-7
Target
Sodium Channel
Related Pathways
Membrane transporter/Ion channel
Bioactivity
Nav1.8-IN-20 (Compound I) is an orally active inhibitor of the voltage-gated sodium channel Nav1.8, with an IC50 value of 14 nM. It effectively blocks the generation and propagation of action potentials in peripheral nociceptive neurons, providing analgesic effects. Nav1.8-IN-20 shows potential for research in several pain types, including acute, chronic, inflammatory, and neuropathic pain.
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O=C(NC1=CN=CN(=O)=C1)C2=CC(Cl)=C(Cl)C=C2OC3=CC=C(OC(F)(F)F)C=C3
Molecular Formula
C18H10Cl2F3N3O4
Molecular Weight
460.19
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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