Nav1.8-IN-6

• UNSPSC Description:

  Nav1.8-IN-6 (Compound 2j) is a novel pyridinone amide Nav1.8 channel inhibitor. The IC50 values in the resting state and semi-activated state are 513.33 and 471.81 nM, respectively. Nav1.8-IN-6 has analgesic activity[1].

• Target Antigen:

  Sodium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/nav1-8-in-6.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC(F)(F)C1=CC=C(C(NC2=CC(NC=C2)=O)=O)C(N3CCC(C(F)(F)F)CC3)=C1

• Molecular Weight:

  433.35

• References & Citations:

  [1]ang Y, et al. Discovery of a novel series of pyridone amides as NaV1.8 inhibitors. Bioorg Med Chem Lett. 2024 Feb 11;101:129655.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported