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Vm24-toxin

CAT: 0804-HY-P5917Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P5917Size:1 Each
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Description
Vm24-toxin (Vaejovis mexicanus peptide 24), a 36-residue peptide, is a potent and selective Kv1.3 blocker with a Kd of ~3 pM in lymphocytes. Vm24-toxin shows >1500-fold affinity for Kv1.3 over other assayed potassium channels. Vm24-toxin folds into a distorted cystine-stabilized α/β motif consisting of a single-turn α-helix and a three-stranded antiparallel β-sheet, stabilized by four disulfide bridges. Vm24-toxin attenuates the CD4+ effector memory T cell response to T cell receptor (TCR) stimulation[1][2].
CAS Number
1373890-79-9
Product Name Alternative
Vaejovis mexicanus peptide 24
UNSPSC
12352209
Target
Potassium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/vm24-toxin.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CO)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCSC)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H]1CCCCN)=O)=O)=O)=O)NC2=O)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CO)C(N3[C@@H](CCC3)C(N[C@@H](CCC(O)=O)C(N[C@@H](CSSC[C@@H](C(N[C@H]4CCCCN)=O)NC1=O)C(N5[C@@H](CCC5)C(N6[C@@H](CCC6)C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC7=CC=C(C=C7)O)C(N[C@H]8CC9=CC=C(C=C9)O)=O)=O)NC4=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H](CSSC[C@@H](C(N)=O)NC8=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(NCC(N[C@H]2CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N
Molecular Formula
C157H253N51O45S9
Molecular Weight
3863.59
References & Citations
[1]Georgina B Gurrola, et al. Structure, function, and chemical synthesis of Vaejovis mexicanus peptide 24: a novel potent blocker of Kv1.3 potassium channels of human T lymphocytes. Biochemistry. 2012, 51, 19.|[2]Veytia-Bucheli JI, et al. Kv1.3 channel blockade with the Vm24 scorpion toxin attenuates the CD4+ effector memory T cell response to TCR stimulation. Cell Commun Signal. 2018 Aug 14;16 (1) :45.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
Voltage-gated potassium channel

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