Vm24-toxin

• Description:

  Vm24-toxin (Vaejovis mexicanus peptide 24), a 36-residue peptide, is a potent and selective Kv1.3 blocker with a Kd of ~3 pM in lymphocytes. Vm24-toxin shows >1500-fold affinity for Kv1.3 over other assayed potassium channels. Vm24-toxin folds into a distorted cystine-stabilized α/β motif consisting of a single-turn α-helix and a three-stranded antiparallel β-sheet, stabilized by four disulfide bridges. Vm24-toxin attenuates the CD4+ effector memory T cell response to T cell receptor (TCR) stimulation[1][2].

• Product Name Alternative:

  Vaejovis mexicanus peptide 24

• UNSPSC:

  12352209

• Target:

  Potassium Channel

• Type:

  Peptides

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/vm24-toxin.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C (N[C@@H] (C) C (N[C@@H] (C) C (N[C@@H] ([C@@H] (C) CC) C (N[C@@H] (CO) C (N[C@@H] (CSSC[C@@H] (C (N[C@@H] (CCSC) C (N[C@@H] (CC (N) =O) C (N[C@@H] (CCCNC (N) =N) C (N[C@H]1CCCCN) =O) =O) =O) =O) NC2=O) C (N[C@@H] (C (C) C) C (NCC (N[C@@H] (CO) C (N3[C@@H] (CCC3) C (N[C@@H] (CCC (O) =O) C (N[C@@H] (CSSC[C@@H] (C (N[C@H]4CCCCN) =O) NC1=O) C (N5[C@@H] (CCC5) C (N6[C@@H] (CCC6) C (N[C@@H] (CCCCN) C (N[C@@H] (CSSC[C@@H] (C (N[C@@H] (CC7=CC=C (C=C7) O) C (N[C@H]8CC9=CC=C (C=C9) O) =O) =O) NC4=O) C (N[C@@H] (CCCNC (N) =N) C (N[C@@H] (C) C (N[C@@H] (CCC (N) =O) C (NCC (N[C@@H] (CSSC[C@@H] (C (N) =O) NC8=O) C (N[C@@H] (CCCCN) C (N[C@@H] (CC (N) =O) C (NCC (N[C@H]2CCCCN) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) [C@H] (C) N

• Molecular Formula:

  C157H253N51O45S9

• Molecular Weight:

  3863.59

• References & Citations:

  [1]Georgina B Gurrola, et al. Structure, function, and chemical synthesis of Vaejovis mexicanus peptide 24: a novel potent blocker of Kv1.3 potassium channels of human T lymphocytes. Biochemistry. 2012, 51, 19.|[2]Veytia-Bucheli JI, et al. Kv1.3 channel blockade with the Vm24 scorpion toxin attenuates the CD4+ effector memory T cell response to TCR stimulation. Cell Commun Signal. 2018 Aug 14;16 (1) :45.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• Isoform:

  Voltage-gated potassium channel

• CAS Number:

  1373890-79-9