HC Toxin

CAT: 0931-T35774-01Size: 500 µgDry Ice: NoHazardous: No

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CAT#:0931-T35774-01Size:500 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

83209-65-8

Target

Apoptosis, Others, HDAC

Related Pathways

Others, Apoptosis, Chromatin/Epigenetic, DNA Damage/DNA Repair

Bioactivity

HC Toxin is a cell-permeable, reversible inhibitor of histone deacetylases (HDACs) (IC50 = 30 nM) . Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells. HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize.

Smiles

C[C@H]1NC(=O)[C@H](CCCCCC(=O)[C@@H]2CO2)NC(=O)[C@H]2CCCN2C(=O)[C@H](C)NC1=O

Molecular Formula

C21H32N4O6

Molecular Weight

436.509

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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HC Toxin

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