HC Toxin

• Target:

  Apoptosis|||Others|||HDAC

• Related Pathways:

  Others|||Apoptosis|||Chromatin/Epigenetic|||DNA Damage/DNA Repair

• Bioactivity:

  HC Toxin is a cell-permeable, reversible inhibitor of histone deacetylases (HDACs) (IC50 = 30 nM) . Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells. HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize.

• Smiles:

  C[C@H]1NC(=O)[C@H](CCCCCC(=O)[C@@H]2CO2)NC(=O)[C@H]2CCCN2C(=O)[C@H](C)NC1=O

• Molecular Formula:

  C21H32N4O6

• Molecular Weight:

  436.509

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  83209-65-8