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ShK toxin

CAT: 0804-HY-P3071Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P3071Size:1 Each
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Description
ShK toxin blocks voltage-dependent potassium channel (Kv1.3 channel) . ShK toxin can be isolated from the whole body extract of the Caribbean sea anemone (Stichodactylu helianthus) . ShK toxin competes with dendrotoxin I and α-dendrotoxin for binding to synaptosomal membranes of rat brain, facilitates acetylcholine release. ShK toxin suppresses K+ currents in cultured rat dorsal root ganglion neurons. ShK toxin also inhibits T lymphocyte proliferation[1][2].
CAS Number
172450-46-3
Product Name Alternative
Stichodactyla helianthus neurotoxin
UNSPSC
12352209
Hazard Statement
H302-H312-H332
Target
Potassium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/shk-toxin.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](CO)C(N[C@@H](CSSC[C@@H](C(O)=O)NC1=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@@H](C)CC)C(N2[C@@H](CCC2)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@H]3[C@H](O)C)=O)=O)=O)NC4=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H](CC5=CC=CC=C5)C(N[C@@H](CCC(N)=O)C(N[C@@H](CSSC[C@@H](C(NCC(N[C@H]1[C@H](O)C)=O)=O)NC3=O)C(N[C@@H](CCCCN)C(N[C@@H](CC6=CNC=N6)C(N[C@@H](CO)C(N[C@@H](CCSC)C(N[C@@H](CCCCN)C(N[C@@H](CC7=CC=C(C=C7)O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@H]4CC8=CC=CC=C8)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCNC(N)=N)N
Molecular Formula
C169H274N54O48S7
Molecular Weight
4054.80
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501
References & Citations
[1]Castañeda O, et al. Characterization of a potassium channel toxin from the Caribbean Sea anemone Stichodactyla helianthus. Toxicon. 1995 May;33 (5) :603-13.|[2]Beeton C, et al. The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation. J Biol Chem. 2008 Jan 11;283 (2) :988-97.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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