Pertussis Toxin

• Description:

  Pertussis Toxin is a protein-based AB5-type exotoxin produced by the bacterium Bordetella pertussis, which causes whooping cough. Pertussis Toxin inhibits G protein-coupled receptor (GPR) signaling through Gi proteins[1][2][3].

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Endogenous Metabolite

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/Pertussis_Toxin.html

• Purity:

  99.0

• Solubility:

  10 mM in DMSO

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Carbonetti NH, et al. Pertussis toxin and adenylate cyclase toxin: key virulence factors of Bordetella pertussis and cell biology tools. Future Microbiol. 2010 Mar;5 (3) :455-69.|[2]Petronila Penela, et al. G protein-coupled receptor kinase 2 positively regulates epithelial cell migration. EMBO J. 2008 Apr 23;27 (8) :1206-18.|[3]Nicholas H Carbonetti, et al. Contribution of pertussis toxin to the pathogenesis of pertussis disease. Pathog Dis. 2015 Nov;73 (8) :ftv073.

• Shipping Conditions:

  Isolate blue ice and the product with bubble pack to avoid direct contact

• Storage Conditions:

  Store at 4°C, do not freeze

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [70323-44-3]