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Nampt activator-5

CAT: 0804-HY-162269Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162269Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nampt activator-5 (compound C8) is a potent nicotinamide phosphoribosyltransferase (NAMPT) activator with a KD value of 6.19 µM. Nampt activator-5 shows a cellular antisenescence effect. Nampt activator-5 promotes the production of NAD+ in the brain and reduces the expression of age-related markers and secretory phenotypes. Nampt activator-5 has the potential for the research of age-related diseases[1].
UNSPSC
12352005
Target
NAMPT
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nampt-activator-5.html
Solubility
10 mM in DMSO
Smiles
O=C(NCC1=CC=NC=C1)NC2=CC=C(S(NCC3=C(C=CC(F)=C3)F)(=O)=O)C=C2
Molecular Formula
C20H18F2N4O3S
Molecular Weight
432.44
References & Citations
[1]Yang S, et al. Discovery of a Potent Nicotinamide Phosphoribosyltransferase Activator for Improving Aging-associated Dysfunctions. J Med Chem. 2024 Feb 17.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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