NAMPT activator-6
CAT:
804-HY-163445
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
NAMPT activator-6
- CAS Number: 2237267-86-4
- UNSPSC Description: NAMPT activator-6 is a NAMPT activator, a regulatory molecule for the optical control system of NAMPT and NAD+. NAMPT activator-6 can be used to design efficient photoswitchable proteolysis-targeting chimeras (PS-PROTACs) to achieve up-down reversible regulation of NAMPT and NAD+ in a light-dependent manner and reduce the toxicity associated with inhibitor-based PS-PROTACs. PS-PROTAC can be used to achieve antitumor activity, NAMPT, and NAD+ modulation in vivo via optical manipulation[1].
- Target Antigen: NAMPT
- Type: Reference compound
- Related Pathways: Metabolic Enzyme/Protease
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/nampt-activator-6.html
- Solubility: 10 mM in DMSO
- Smiles: O=C(NCC1=CC=NC=C1)NC2=CC=C(S(=O)(N3CCNCC3)=O)C=C2
- Molecular Weight: 375.45
- References & Citations: [1]Cheng J, et al. Photoswitchable PROTACs for Reversible and Spatiotemporal Regulation of NAMPT and NAD. Angew Chem Int Ed Engl. 2024 Mar 18;63(12):e202315997.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported