Products for Research Use Only
RegisterLogin

Nampt-IN-5

CAT: 0804-HY-130606-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-130606-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Nampt-IN-5 is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-5 also inhibits CYP3A4 activity and has cellular IC50s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively[1].
CAS Number
2380013-17-0
UNSPSC
12352005
Target
Cytochrome P450; NAMPT
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nampt-in-5.html
Purity
98.02
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N1CC(C2=CC=CN=C2)C1)NC3=CC=C(CN4C5=CC=CC=C5N=C4OCC)C=C3
Molecular Formula
C25H25N5O2
Molecular Weight
427.50
References & Citations
[1]Palacios DS, et al. Scaffold Morphing Identifies 3-Pyridyl Azetidine Ureas as Inhibitors of Nicotinamide Phosphoribosyltransferase (NAMPT) .ACS Med Chem Lett. 2019 Oct 10;10 (11) :1524-1529.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP3

Chemical Information

Nampt-IN-5
CAS Number2380013-17-0
PubChem CID146014464
IUPAC NameN-[4-[(2-ethoxybenzimidazol-1-yl)methyl]phenyl]-3-pyridin-3-ylazetidine-1-carboxamide
Molecular FormulaC25H25N5O2
Molecular Weight427.5
XLogP3.3
Topological Polar Surface Area72.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Heavy Atom Count32
Formal Charge0
Complexity619
SMILES
CCOC1=NC2=CC=CC=C2N1CC3=CC=C(C=C3)NC(=O)N4CC(C4)C5=CN=CC=C5
InChI
InChI=1S/C25H25N5O2/c1-2-32-25-28-22-7-3-4-8-23(22)30(25)15-18-9-11-21(12-10-18)27-24(31)29-16-20(17-29)19-6-5-13-26-14-19/h3-14,20H,2,15-17H2,1H3,(H,27,31)
InChIKey
JWEBCHOGBDMGBY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Nampt-IN-5
CAS: 2380013-17-0
CID: 146014464
Formula: C25H25N5O2
MW: 427.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight427.5
XLogP33.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass427.20082506
Monoisotopic Mass427.20082506
Topological Polar Surface Area72.3 Ų
Heavy Atom Count32
Formal Charge0
Complexity619
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-147838Nampt-IN-9
HY-12971-01Nampt-IN-1
HY-402237-01Nampt-IN-15
HY-147756Nampt-IN-7
HY-W1117786Nampt-IN-10
HY-164759Nampt-IN-13
HY-147795Nampt-IN-8
HY-108701-01Nampt-IN-3
HY-176237Nampt-IN-16
HY-P701314-01NAMPT, Mouse

Alternative Products

CatalogName
BA7262-10Nampt-IN-5
GTR19262047-01Nampt activator-5
325230-01NAMPT
BA8044-10Nampt-IN-1
BA3116-1Nampt-IN-3
T210565-01Nampt-IN-16
T61597-01Nampt-IN-7
GTR17893283-01NAMPT Antibody

Popular Products