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Nampt-IN-15

CAT: 0804-HY-402237-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-402237-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nampt-IN-15 (Example 3) is an Nampt inhibitor. Nampt-IN-15 shows cytotoxicity against BxPC-3, HepG2, L540cy and MOLM-13, with IC50s of 38.5 nM, 8 nM, 8.5 nM, 7 nM respectively[1].
CAS Number
2222981-61-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
NAMPT
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nampt-in-15.html
Concentration
10mM
Purity
99.49
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC(N)=CC=C1)N2CCC(CC2)CCCCNC(/C=C/C3=CN=CC=C3)=O
Molecular Formula
C24H30N4O2
Molecular Weight
406.52
Precautions
H302, H315, H319, H335
References & Citations
[1]Christopher Scott NEUMANN, et al. Targeted delivery of nicotinamide adenine dinucleotide salvage pathway inhibitors. Patent. WO2018075600
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Nampt-IN-15
CAS Number2222981-61-3
PubChem CID134458913
IUPAC Name(E)-N-[4-[1-(3-aminobenzoyl)piperidin-4-yl]butyl]-3-pyridin-3-ylprop-2-enamide
Molecular FormulaC24H30N4O2
Molecular Weight406.5
XLogP3
Topological Polar Surface Area88.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count8
Heavy Atom Count30
Formal Charge0
Complexity572
SMILES
C1CN(CCC1CCCCNC(=O)/C=C/C2=CN=CC=C2)C(=O)C3=CC(=CC=C3)N
InChI
InChI=1S/C24H30N4O2/c25-22-8-3-7-21(17-22)24(30)28-15-11-19(12-16-28)5-1-2-14-27-23(29)10-9-20-6-4-13-26-18-20/h3-4,6-10,13,17-19H,1-2,5,11-12,14-16,25H2,(H,27,29)/b10-9+
InChIKey
JLAJCUOAEWKJJS-MDZDMXLPSA-N
Chemical Structure
2D Structure
2D structure of Nampt-IN-15
CAS: 2222981-61-3
CID: 134458913
Formula: C24H30N4O2
MW: 406.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight406.5
XLogP33
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count8
Exact Mass406.23687621
Monoisotopic Mass406.23687621
Topological Polar Surface Area88.3 Ų
Heavy Atom Count30
Formal Charge0
Complexity572
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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