COX-1/2-IN-8

• UNSPSC Description:

  COX-1/2-IN-8 (compound 11f) is an orally active and potent inhibitor of COX-1 and COX-2, with IC50 values of 2.14 and 0.58 µM, respectively. COX-1/2-IN-8 displays a higher significant anti-inflammatory activity than Celecoxib (HY-14398)[1].

• Target Antigen:

  COX

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/cox-1-2-in-8.html

• Smiles:

  O=C(C1=CC=CC=C1)CSC2=NN=C(C(N3CC4=C(C=CC=C4)CC3)C5=CC=CC=C5)N2C6=CC=C(C)C=C6

• Molecular Weight:

  530.68

• References & Citations:

  [1]Abo-Elmagd MI, et al. Design, synthesis and anti-inflammatory assessment of certain substituted 1,2,4-triazoles bearing tetrahydroisoquinoline scaffold as COX 1/2-inhibitors. Bioorg Chem. 2024 Sep;150:107577.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported