COX-1/2-IN-4

CAT: 0804-HY-155764Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-155764Size:1 Each

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Description

COX-1/2-IN-4 (compound 2b) is anCOX inhibitorwith IC50 values of 0.239 μM and 0.191 μM for COX-1 enzyme and COX-2 enzyme , respectively. COX-1/2-IN-4showsmoderateanticanceractivity against COLO205 and B16F1 cancer cell lines with IC50 values of 30.79 and 74.15 μM, respectively[1].

CAS Number

2967296-91-7

UNSPSC

12352005

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cox-1-2-in-4.html

Solubility

10 mM in DMSO

Smiles

CC(C)(C)C(C=C1)=CC=C1NC(C(S2)=C(N=C2C3=CC=CC(OC)=C3)C)=O

Molecular Formula

C22H24N2O2S

Molecular Weight

380.50

References & Citations

[1]Mohammed Hawash, et al. New Thiazole Carboxamide Derivatives as COX Inhibitors: Design, Synthesis, Anticancer Screening, In Silico Molecular Docking, and ADME Profile Studies. ACS Omega.2023, 8, 32.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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HY-146704	COX-2/sEH-IN-1
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Alternative Products

Catalog	Name
T79592-01	COX-1/2-IN-4
C7904-89C	COX 4-1 (COX IV-1)
MBS5803131	COX-2/NO-IN-1
GTR19239148-01	COX-1-IN-2
M26018-01	COX-2-IN-1
T61865-01	COX-1/2-IN-2
GTR19187365-01	COX-1/2-IN-1
TBS2121	Cyclooxygenase (COX-1, COX-2) Inhibition Assay
COX2081	Control for COX-2, 4 cases (1.5mm)
T209627-01	INOS/COX-2-IN-1

COX-1/2-IN-4

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