COX-2/sEH-IN-1

COX-2/sEH-IN-1

• CAS Number: 2474977-38-1
• UNSPSC Description: COX-2/sEH-IN-1 (Compound 9c) is an orally active, dual COX-2 and sEH (soluble epoxide hydrolase) inhibitor with IC50 values of 1.24 μM and 0.40 nM against COX-2 and sEH, respectively. COX-2/sEH-IN-1 shows improved anti-inflammatory activity and highly reduced cardiovascular risks[1].
• Target Antigen: COX; Epoxide Hydrolase
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease
• Applications: Neuroscience-Neuromodulation
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/cox-2-seh-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: NS(=O)(C1=CC=C(C=C1)N2N=C(C=C2C3=CC=CC=C3)NC(NC4=CC=C(C=C4)C(F)(F)F)=O)=O
• Molecular Weight: 501.48
• References & Citations: [1]Ahmed H Abdelazeem, et al. Discovery of novel urea-diarylpyrazole hybrids as dual COX-2/sEH inhibitors with improved anti-inflammatory activity and highly reduced cardiovascular risks. Eur J Med Chem. 2020 Nov 1;205:112662.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported