LK-60

• Description :

  LK-60 is a potent DprE1 inhibitor. LK-60 effectively inhibits the proliferation of Mycobacterium tuberculosis. LK-60 has good safety profiles to gut microbiota and human cells[1].

• UNSPSC :

  12352005

• Target :

  Bacterial

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/lk-60.html

• Concentration :

  10mM

• Purity :

  99.70

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C1N=C(N2C(NC3=CC=CC(C(F)(F)F)=C3)=CC(C)=N2)NC(CC)=C1

• Molecular Formula :

  C17H16F3N5O

• Molecular Weight :

  363.34

• References & Citations :

  [1]Yang L, et al. Discovery of N- (1- (6-Oxo-1,6-dihydropyrimidine) -pyrazole) Acetamide Derivatives as Novel Noncovalent DprE1 Inhibitors against Mycobacterium tuberculosis. J Med Chem. 2024 Jan 17.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported