LK-44

• UNSPSC Description:

  hCES2A-IN-2 (Compound 44) is an orally active human carboxylesterase 2 (hCES2A) inhibitor (IC50: 5.02 μM). hCES2A-IN-2 improves Irinotecan (HY-16562)-induced delayed diarrhea[1].

• Target Antigen:

  Others

• Type:

  Reference compound

• Related Pathways:

  Others

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/lk-44.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCCOC1=CC=C(C(/C(O2)=C/C3=CC(Cl)=C(OC(C)(C)C(O)=O)C=C3)=O)C2=C1

• Molecular Weight:

  416.85

• References & Citations:

  [1]Yang Z, et al. Design, synthesis, and biological evaluation studies of novel carboxylesterase 2 inhibitors for the treatment of irinotecan-induced delayed diarrhea. Bioorg Chem. 2023 Sep;138:106625.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported