G007-LK

• Description:

  G007-LK is a potent and selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  PARP

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/G007-LK.html

• Concentration:

  10mM

• Purity:

  99.24

• Solubility:

  DMSO : ≥ 30 mg/mL

• Smiles:

  ClC1=C (C=CC=C1) N2C (/C=C/C3=NN=C (C4=CC=C (C#N) C=C4) O3) =NN=C2C5=CC=C (S (C) (=O) =O) C=N5

• Molecular Formula:

  C25H16ClN7O3S

• Molecular Weight:

  529.96

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Voronkov A, et al. Structural basis and SAR for G007-LK, a lead stage 1,2,4-triazole based specific tankyrase 1/2 inhibitor. J Med Chem. 2013 Apr 11;56 (7) :3012-23.|[2]Norum JH, et al. The tankyrase inhibitor G007-LK inhibits small intestine LGR5+ stem cell proliferation without altering tissue morphology. Biol Res. 2018 Jan 9;51 (1) :3.|[3]Xin Chen, et al. Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via modulating the Hippo cascade. PLoS One. 2017 Sep 6;12 (9) :e0184068.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  TNKS1/PARP5A; TNKS2/PARP5B

• CAS Number:

  1380672-07-0