LK-2

• Description:

  LK-2 is an antagonist for ASIC1a with a Kd of 1.9 μM. LK-2 reduces glutamate-induced ASIC1a current-enhancement with an IC50 of 6.6 μM. LK-2 exhibits neuroprotective efficacy in mouse ischemic stroke model, with improved motor and coordination skills. LK-2 is blood-brain barrier (BBB) penetrable[1].

• UNSPSC:

  12352005

• Target:

  Sodium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/lk-2.html

• Purity:

  98.83

• Solubility:

  H2O : 50 mg/mL (ultrasonic)

• Smiles:

  OP(C(C1=CC=CC=C1)N2CC(C(O)=O)NCC2)(O)=O

• Molecular Formula:

  C12H17N2O5P

• Molecular Weight:

  300.25

• References & Citations:

  [1]Lai K, et al., Glutamate acts on acid-sensing ion channels to worsen ischaemic brain injury. Nature. 2024 Jul;631 (8022) :826-834.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2649762-09-2]