LK-2

CAT: 0804-HY-164284-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-164284-01Size:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
LK-2 is an antagonist for ASIC1a with a Kd of 1.9 μM. LK-2 reduces glutamate-induced ASIC1a current-enhancement with an IC50 of 6.6 μM. LK-2 exhibits neuroprotective efficacy in mouse ischemic stroke model, with improved motor and coordination skills. LK-2 is blood-brain barrier (BBB) penetrable[1].
CAS Number
[2649762-09-2]
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lk-2.html
Purity
98.83
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
OP(C(C1=CC=CC=C1)N2CC(C(O)=O)NCC2)(O)=O
Molecular Formula
C12H17N2O5P
Molecular Weight
300.25
References & Citations
[1]Lai K, et al., Glutamate acts on acid-sensing ion channels to worsen ischaemic brain injury. Nature. 2024 Jul;631 (8022) :826-834.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-12438-01G007-LK
HY-161178-01LK-60
HY-167858LK-732
HY-126164-01LK 614
HY-P990614-01LK-1
HY-155228LK-44
HY-121318LK 11
HY-129660LK 204-545
HY-W011060-01Cryptand 2.2.2
HY-B1500-012,2,2-Trichloroethanol

Alternative Products

CatalogName
ARC0443LK-2
APR16776GMonoclonal HSPD1 / HSP60 Antibody (clone LK-2), Clone: LK-2
RWT-652LK-2 Cell Line
MBS384734-01G007-LK
MF-0101240-01LK-1
MF-0141106-01LK 157
ADI-SPA-807-EHSP60 monoclonal antibody (LK-2)
BUP01112-01LK-614
MBS131199-01LK-0037
MF-0111005-01LK-732

Popular Products