(2R,3S)-PD-1/PD-L1-IN-38

(2R,3S)-PD-1/PD-L1-IN-38

• UNSPSC Description: (2R,3S)-PD-1/PD-L1-IN-38 (Compound (±)-13e) is an orally active Ah receptor (AhR) antagonist with in vivo and in vitro anticancer activity. (2R,3S)-PD-1/PD-L1-IN-38 promotes the secretion of INF-γ by CD8+T cells and inhibits the signal transduction of PD-1/PD-L1[1].
• Target Antigen: Aryl Hydrocarbon Receptor; PD-1/PD-L1
• Type: Natural Products
• Related Pathways: Immunology/Inflammation
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/2r-3s-pd-1-pd-l1-in-38.html
• Solubility: 10 mM in DMSO
• Smiles: CC(C1=CC2=C(C3=C(C(C)=C(C=C3)C)C=C2)C4=C1O[C@@H](OC(C)=O)[C@@H](C5=CC=CC=C5)O4)C
• Molecular Weight: 440.53
• References & Citations: [1]Li Z, et al. Discovery of Natural Ah Receptor Antagonists from Salvia miltiorrhiza Bunge and Synthesis of Analogs for Tumor Immunotherapy[J]. Journal of Medicinal Chemistry, 2024.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported