PD-1/PD-L1-IN-39

PD-1/PD-L1-IN-39

• UNSPSC Description: PD-1/PD-L1-IN-39 (X 14) is an orally active PD-1/PD-L1 inhibitor with a IC50 value of 15.73 nM. PD-1/ PD-L1-in-39 has a good binding affinity for human and mouse PD-L1, with KD values of 14.62 nM and 392 nM, respectively. PD-1/PD-L1-IN-39 has antitumor activity[1].
• Target Antigen: PD-1/PD-L1
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pd-1-pd-l1-in-39.html
• Solubility: 10 mM in DMSO
• Smiles: ClC1=C(C=CC=C1C2=C(C=CC=C2)F)COC3=NC4=C(C=C3)CN(CC(O)=O)CC4
• Molecular Weight: 426.87
• References & Citations: [1]Xu Y, et al. Discovery of Highly Potent Small-Molecule PD-1/PD-L1 Inhibitors with a Novel Scaffold for Cancer Immunotherapy. J Med Chem. 2024 Feb 13.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported