PD-1/PD-L1-IN-39

• UNSPSC Description:

  PD-1/PD-L1-IN-39 (X 14) is an orally active PD-1/PD-L1 inhibitor with a IC50 value of 15.73 nM. PD-1/ PD-L1-in-39 has a good binding affinity for human and mouse PD-L1, with KD values of 14.62 nM and 392 nM, respectively. PD-1/PD-L1-IN-39 has antitumor activity[1].

• Target Antigen:

  PD-1/PD-L1

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pd-1-pd-l1-in-39.html

• Solubility:

  10 mM in DMSO

• Smiles:

  ClC1=C(C=CC=C1C2=C(C=CC=C2)F)COC3=NC4=C(C=C3)CN(CC(O)=O)CC4

• Molecular Weight:

  426.87

• References & Citations:

  [1]Xu Y, et al. Discovery of Highly Potent Small-Molecule PD-1/PD-L1 Inhibitors with a Novel Scaffold for Cancer Immunotherapy. J Med Chem. 2024 Feb 13.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported