PD-1/PD-L1-IN-25

PD-1/PD-L1-IN-25

• CAS Number: 2768759-52-8
• UNSPSC Description: PD-1/PD-L1-IN-25 (compound D2) is an inhibitor of PD-1/PD-L1 interaction with an IC50 value of 16.17 nM. PD-1/PD-L1-IN-25 activates the antitumor immunity of T cells efficiently in PBMCs. PD-1/PD-L1-IN-25 can be used for the research of cancer[1].
• Target Antigen: PD-1/PD-L1
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pd-1-pd-l1-in-25.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=C(C(C2=CC3=C(OCCO3)C=C2)=CC=C1)Cl)NC4=NC=C(C=C4)CN5CC[C@@H](C5)C(O)=O
• Molecular Weight: 493.94
• References & Citations: [1]Lu L, et al. Design, Synthesis, and Evaluation of PD-1/PD-L1 Antagonists Bearing a Benzamide Scaffold. ACS Med Chem Lett. 2022 Mar 29;13(4):586-592.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported