PD-1/PD-L1-IN-15

PD-1/PD-L1-IN-15

• UNSPSC Description: PD-1/PD-L1-IN-15 (Compound M17) is a potent inhibitor of PD-1/PD-L1 with an IC50 value of 60.1 nM. PD-1/PD-L1-IN-15 has the potential for the research of tumor immunoresearch[1].
• Target Antigen: PD-1/PD-L1
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pd-1-pd-l1-in-15.html
• Solubility: 10 mM in DMSO
• Smiles: N#CC1=CN=CC(COC2=CC(C(N3CCC4=C3C=CC=C4C5=CC=CC=C5)=O)=CC=C2CN(C)CCO)=C1
• Molecular Weight: 518.61
• References & Citations: [1]Meng Y, et al. Discovery of 4-phenylindolines containing a (5-cyanopyridin-3-yl)methoxy moiety as potent inhibitors of the PD-1/PD-L1 interaction. Bioorg Med Chem Lett. 2022 May 1;63:128647
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported