PD-1/PD-L1-IN-15

• UNSPSC Description:

  PD-1/PD-L1-IN-15 (Compound M17) is a potent inhibitor of PD-1/PD-L1 with an IC50 value of 60.1 nM. PD-1/PD-L1-IN-15 has the potential for the research of tumor immunoresearch[1].

• Target Antigen:

  PD-1/PD-L1

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pd-1-pd-l1-in-15.html

• Solubility:

  10 mM in DMSO

• Smiles:

  N#CC1=CN=CC(COC2=CC(C(N3CCC4=C3C=CC=C4C5=CC=CC=C5)=O)=CC=C2CN(C)CCO)=C1

• Molecular Weight:

  518.61

• References & Citations:

  [1]Meng Y, et al. Discovery of 4-phenylindolines containing a (5-cyanopyridin-3-yl)methoxy moiety as potent inhibitors of the PD-1/PD-L1 interaction. Bioorg Med Chem Lett. 2022 May 1;63:128647

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported