ML 10302

CAT: 0804-HY-14441-01Size: 5 mgDry Ice: NoHazardous: No

CAT#:0804-HY-14441-01Size:5 mg

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Description

ML 10302 is a potent agonist 5-HT4 receptor with Ki of 1.07 nM. 5-Hydroxytryptamine (5-HT4) receptor agonists stimulate gut motility through cholinergic pathways. ML10302 induces significant prokinesia both in the small bowel and colon through activation of cholinergic pathways. ML 10302 also has the potential for the research of neurology diseases[1].

CAS Number

[148868-55-7]

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ml-10302.html

Purity

98.95

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(OCCN1CCCCC1)C2=CC(Cl)=C(N)C=C2OC

Molecular Formula

C15H21ClN2O3

Molecular Weight

312.79

References & Citations

[1] Cachard-Chastel M, et al. 5-HT4 receptor agonists increase sAPPalpha levels in the cortex and hippocampus of male C57BL/6j mice. Br J Pharmacol. 2007;150 (7) :883-892.|[2]Yang D, et al. New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors. J Med Chem. 1997;40 (4) :608-621.|[3]De Ponti F, et al. Intestinal motor stimulation by the 5-HT4 receptor agonist ML10302: differential involvement of tachykininergic pathways in the canine small bowel and colon. Neurogastroenterol Motil. 2001;13 (6) :543-553.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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