ML-B01

• Description :

  ML-B01 is the orally active inhibitor for Akt and PKA with the IC50 of 2 nM and 136 nM. ML-B01 exhibits good ability to penetrate the blood-brain barrier (BBB) in the mouse brain[1].

• UNSPSC :

  12352005

• Target :

  Akt; PKA

• Related Pathways :

  PI3K/Akt/mTOR; Stem Cell/Wnt; TGF-beta/Smad

• Field of Research :

  Cancer

• Smiles :

  O=C(N1CCN(C2=C([C@H](C)C[C@H]3Cl)C3=NC=N2)CC1)[C@@H](C4=CC=C(Cl)C=C4)CNC(C)C

• Molecular Formula :

  C24H31Cl2N5O

• Molecular Weight :

  476.44

• References & Citations :

  [1]Wu Y, et al., Pharmacodynamics of Akt drugs revealed by a kinase-modulated bioluminescent indicator. Nat Chem Biol. 2025 Feb 11.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported