ML 297

CAT: 0804-HY-110192-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-110192-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
ML 297 (VU 0456810) is a potent and selective GIRK1/2 activator, with an EC50 of 0.16 μM. ML 297 is potential for the treatment of epilepsy[1][2].
CAS Number
[1443246-62-5]
Product Name Alternative
VU 0456810; CID 56642816
UNSPSC
12352005
Hazard Statement
H410
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ml-297.html
Purity
99.14
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
FC1=C(F)C=CC(NC(NC2=CC(C)=NN2C3=CC=CC=C3)=O)=C1
Molecular Formula
C17H14F2N4O
Molecular Weight
328.32
Precautions
H410
References & Citations
[1]Wen W, et al. Discovery of 'molecular switches' within a GIRK activator scaffold that afford selective GIRK inhibitors. Bioorg Med Chem Lett. 2013 Aug 15;23 (16) :4562-6.|[2]Kaufmann K, et al. ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice. ACS Chem Neurosci. 2013 Sep 18;4 (9) :1278-86.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-119248-01KRP-297
HY-120271GGTI-297
HY-114504-01RVX-297
HY-W953117CRBN ligand-297
HY-178781Antibacterial agent 297
HY-RI04327A-01Rno-miR-297 antagomir
HY-R04327-01Rno-miR-297 mimic
HY-R00506A-01Hsa-miR-297 agomir
HY-R00506-01Hsa-miR-297 mimic
HY-RI00506-01Hsa-miR-297 inhibitor

Alternative Products

CatalogName
APPDE 100Plasmid DNA Extraction Mini Kit (100prep) (sample size:1~3 ml culture)
APHPD 100High Yield Plasmid Extraction Mini Kit (100prep) (sample size:1~5 ml culture)
APHPD 300High Yield Plasmid Extraction Mini Kit (300prep) (sample size:1~5 ml culture)
APPCK 050PCR Clean-Up Mini Kit (50prep)
APBGK 100Blood Genomic DNA Extraction Mini Kit (100prep), (With Proteinase K Powder, for wide applications and simple procedure)
APBGR 200Blood Genomic DNA Extraction Mini Kit (200prep) (With RBC buffer)
APTGK 050Tissue Genomic DNA Extraction Mini Kit (50prep), with Proteinase K Powder
APPGK 050Plant Genomic DNA Extraction Mini Kit (50prep)
APDSC 050DNA Sequencing Clean-Up Kit (50prep)
APFDK 050Food DNA Extraction Kit (50prep)

Popular Products