ML 297

• Description :

  ML 297 (VU 0456810) is a potent and selective GIRK1/2 activator, with an EC50 of 0.16 μM. ML 297 is potential for the treatment of epilepsy[1][2].

• Product Name Alternative :

  VU 0456810; CID 56642816

• UNSPSC :

  12352005

• Hazard Statement :

  H410

• Target :

  Potassium Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/ml-297.html

• Purity :

  99.14

• Solubility :

  DMSO : 250 mg/mL (ultrasonic)

• Smiles :

  FC1=C(F)C=CC(NC(NC2=CC(C)=NN2C3=CC=CC=C3)=O)=C1

• Molecular Formula :

  C17H14F2N4O

• Molecular Weight :

  328.32

• Precautions :

  H410

• References & Citations :

  [1]Wen W, et al. Discovery of 'molecular switches' within a GIRK activator scaffold that afford selective GIRK inhibitors. Bioorg Med Chem Lett. 2013 Aug 15;23 (16) :4562-6.|[2]Kaufmann K, et al. ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice. ACS Chem Neurosci. 2013 Sep 18;4 (9) :1278-86.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1443246-62-5]