ML-SA1

CAT: 0804-HY-108462-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-108462-01Size:5 mg
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AVAILABILITY: InStock
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Description
ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral[1].
CAS Number
[332382-54-4]
UNSPSC
12352005
Hazard Statement
H301, H410
Target
Dengue Virus; Flavivirus; TRP Channel
Type
Reference compound
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ml-sa1.html
Purity
99.44
Solubility
DMSO : 20.83 mg/mL (ultrasonic; warming; heat to 65°C)
Smiles
O=C1N(CC(N2C(C)(C)CC(C)C3=C2C=CC=C3)=O)C(C4=C1C=CC=C4)=O
Molecular Formula
C22H22N2O3
Molecular Weight
362.42
Precautions
H301, H410
References & Citations
[1]Xia Z, et al. ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity. Antiviral Res. 2020;182:104922.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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