ML-SA1

• Description :

  ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H410

• Target :

  Dengue Virus; Flavivirus; TRP Channel

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/ml-sa1.html

• Purity :

  99.44

• Solubility :

  DMSO : 20.83 mg/mL (ultrasonic; warming; heat to 65°C)

• Smiles :

  O=C1N(CC(N2C(C)(C)CC(C)C3=C2C=CC=C3)=O)C(C4=C1C=CC=C4)=O

• Molecular Formula :

  C22H22N2O3

• Molecular Weight :

  362.42

• Precautions :

  H301, H410

• References & Citations :

  [1]Xia Z, et al. ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity. Antiviral Res. 2020;182:104922.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [332382-54-4]