ML-SA1

ML-SA1

• CAS Number: 332382-54-4
• UNSPSC Description: ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral[1].
• Target Antigen: Dengue virus; Flavivirus; TRP Channel
• Type: Reference compound
• Related Pathways: Anti-infection;Membrane Transporter/Ion Channel;Neuronal Signaling
• Applications: COVID-19-anti-virus
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/ml-sa1.html
• Purity: 99.33
• Solubility: DMSO : 20.83 mg/mL (ultrasonic;warming;heat to 65°C)
• Smiles: O=C1N(CC(N2C(C)(C)CC(C)C3=C2C=CC=C3)=O)C(C4=C1C=CC=C4)=O
• Molecular Weight: 362.42
• References & Citations: [1]Xia Z, et al. ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity. Antiviral Res. 2020;182:104922.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported