ML-SA1

• UNSPSC Description:

  ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral[1].

• Target Antigen:

  Dengue virus; Flavivirus; TRP Channel

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Membrane Transporter/Ion Channel;Neuronal Signaling

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/ml-sa1.html

• Purity:

  99.33

• Solubility:

  DMSO : 20.83 mg/mL (ultrasonic;warming;heat to 65°C)

• Smiles:

  O=C1N(CC(N2C(C)(C)CC(C)C3=C2C=CC=C3)=O)C(C4=C1C=CC=C4)=O

• Molecular Weight:

  362.42

• References & Citations:

  [1]Xia Z, et al. ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity. Antiviral Res. 2020;182:104922.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  332382-54-4