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Thioetheramide-PC

CAT: 0804-HY-133233Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-133233Size:1 Each
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Description
Thioetheramide-PC (1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine) is a structurally modified phospholipid that acts as a competitive, reversible inhibitor of secretory phospholipase A2 (sPLA2) . Thioetheramide-PC has an IC50 value of 2 μM at a substrate concentration of 0.5 mM. In addition to binding to the catalytic site of sPLA2, Thioetheramide-PC also binds to the activation site of the enzyme. Thioetheramide-PC binds more tightly to the activation site than to the catalytic site. As a result of this dual interaction, at low concentrations, Thioetheramide-PC may activate phospholipase activity rather than inhibit it.
CAS Number
[116457-99-9]
Product Name Alternative
1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine
UNSPSC
12352211
Target
Endogenous Metabolite; Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/thioetheramide-pc.html
Smiles
CCCCCCCCCCCCCCCCSC[C@@H](NC(CCCCCCCCCCCCCCC)=O)COP(OCC[N+](C)(C)C)([O-])=O
Molecular Formula
C40H83N2O5PS
Molecular Weight
735.14
References & Citations
[1]Yu, et al. The interaction of phospholipase A2 with phospholipid analogues and inhibitors. J. Biol. Chem. 265, 2657-2664 (1990) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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