GNE-783

CAT: 0804-HY-15882Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-15882Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
GNE-783 is a selective CHK1 inhibitor that enhances the activity of gemcitabine. GNE-783 improves the efficacy of anti-metabolite DNA damage drugs by inactivating S-phase and G2-phase cell cycle checkpoints following DNA damage. GNE-783 selectively enhances the chemical synergy of certain drugs in different tumor types, for example, enhancing the activity of temozolomide only in melanoma cell lines[1].
CAS Number
[1200127-66-7]
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gne-783.html
Smiles
N#CC1=NC=C2C(C3=CC(C4=CC=C(N5CCN(C)CC5)C=C4)=CN=C3N2)=C1
Molecular Formula
C22H20N6
Molecular Weight
368.43
References & Citations
[1]Identification of preferred chemotherapeutics for combining with a CHK1 inhibitor
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-179131TN-783
HY-139109-01IR-783
HY-W999657CRBN ligand-783
HY-175448GNE-1567
HY-15883-01GNE-900
HY-18163-01GNE-7915
HY-149026-01GNE-064
HY-15766-01GNE-617
HY-150289-01GNE-235
HY-107986-01GNE-6776

Alternative Products

CatalogName
MF-0140879-01GNE-783
463884IR 783
MBS3613022-01IR-783
329920PLCg1 (Ab-783)
400606-01GNE
A74656-100ULPLCG1 (Ab-783) Antibody
MBS435182-01ATP5A (783) Mouse mAb
MBS9413348-01PLCgamma1 (Ab-783) Antibody
ANTY021129PLCγ1(Ab-783)
79-552PLCgamma1 (Ab 783) Antibody

Popular Products