Products for Research Use Only
RegisterLogin

GNE-2256

CAT: 0804-HY-148238Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-148238Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
GNE-2256 (molecule 19), a chemical probe, is an orally active IRAK4 (Interleukin 1 receptor associated kinase 4) inhibitor (IRAK4 Ki=1.4 nM; IL-6 IC50=190 nM) [1].
CAS Number
2102170-43-2
UNSPSC
12352005
Target
IRAK
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gne-2256.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C2N(C=CC=N2)N=C1)NC3=C(N4CCOCC4)C=C5C(CN(C5=O)C[C@@H](F)C(C)(O)C)=C3
Molecular Formula
C24H27FN6O4
Molecular Weight
482.51
References & Citations
[1]Rajapaksa NS, et al. Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity. ACS Med Chem Lett. 2019 Nov 11;11 (3) :327-333.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IRAK4

Related Products

CatalogName
HY-142160-01GNE-9815
HY-108696-01GNE-781
HY-114332-01GNE-8505
HY-15882GNE-783
HY-126291GNE-616
HY-12947-01GNE-3511
HY-12632-01GNE 2861
HY-132294-01GNE-502
HY-120028-01GNE-207
HY-12763-01GNE-317

Alternative Products

CatalogName
MBS5815522GNE-2256
101802WO-2256 Inspection & Calibration Labels
317648GNE
BA8317-5GNE-6468
B4991-50GNE-317
BA4704-10GNE-375
BA3885-5GNE-6776
B1271-100GNE-617
BA8045-50GNE-618
B8001-5GNE-477

Popular Products