GNE 220

• UNSPSC Description:

  GNE-220 is a potent and selective inhibitor of MAP4K4 with an IC50 of 7 nM.

• Target Antigen:

  MAP4K

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/GNE_220.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CN1N=CC(C2=NC(C)=C(NC3=NC=C(C4=CC=C(N5CCN(C)CC5)C=C4)C=C36)C6=N2)=C1

• Molecular Weight:

  438.53

• References & Citations:

  [1]Vitorino P, et al. MAP4K4 regulates integrin-FERM binding to control endothelial cell motility. Nature. 2015 Mar 26;519(7544):425-30.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1199590-75-4