GNE 220

CAT: 0804-HY-U00428Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-U00428Size:1 Each
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Description
GNE-220 is a potent and selective inhibitor of MAP4K4 with an IC50 of 7 nM.
CAS Number
[1199590-75-4]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
MAP4K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GNE_220.html
Solubility
10 mM in DMSO
Smiles
CN1N=CC(C2=NC(C)=C(NC3=NC=C(C4=CC=C(N5CCN(C)CC5)C=C4)C=C36)C6=N2)=C1
Molecular Formula
C25H26N8
Molecular Weight
438.53
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Vitorino P, et al. MAP4K4 regulates integrin-FERM binding to control endothelial cell motility. Nature. 2015 Mar 26;519 (7544) :425-30.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAP4K4/HGK; MAP4K5/KHS1; MAP4K6/MINK1

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