GNE 220

• Description :

  GNE-220 is a potent and selective inhibitor of MAP4K4 with an IC50 of 7 nM.

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  MAP4K

• Type :

  Reference compound

• Related Pathways :

  MAPK/ERK Pathway

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/GNE_220.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CN1N=CC(C2=NC(C)=C(NC3=NC=C(C4=CC=C(N5CCN(C)CC5)C=C4)C=C36)C6=N2)=C1

• Molecular Formula :

  C25H26N8

• Molecular Weight :

  438.53

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]Vitorino P, et al. MAP4K4 regulates integrin-FERM binding to control endothelial cell motility. Nature. 2015 Mar 26;519 (7544) :425-30.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MAP4K4/HGK; MAP4K5/KHS1; MAP4K6/MINK1

• CAS Number :

  [1199590-75-4]