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GNE-900

CAT: 0804-HY-15883-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15883-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GNE-900 is a an ATP-competitive, selective, and orally active ChK1 inhibitor with IC50s of 0.0011, 1.5 μM for ChKl, ChK2, respectively. GNE-900 abrogates the G2-M checkpoint, enhances DNA damage, and induces Apoptosis. Gemcitabine and GNE-900 administration shows anti-tumor activity[1].
CAS Number
1200126-26-6
UNSPSC
12352005
Target
Apoptosis; Checkpoint Kinase (Chk)
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gne-900.html
Purity
99.21
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
N#CC1=NC=C2C(C3=CC(C4=CC=C(CN5CCCCC5)C=C4)=CN=C3N2)=C1
Molecular Formula
C23H21N5
Molecular Weight
367.45
References & Citations
[1]Blackwood E, et al. Combination drug scheduling defines a "window of opportunity" for chemopotentiation of gemcitabine by an orally bioavailable, selective ChK1 inhibitor, GNE-900. Mol Cancer Ther. 2013 Oct;12 (10) :1968-80.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Chk1; Chk2

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