CPPG

• Description :

  CPPG ((RS) -CPPG) is a potent group II/III mGlu receptors antagonist. CPPG exhibits some selectivity (approximately 20 fold) for group III (IC50=2.2 nM) over group II (IC50=46.2 nM) mGlu receptors in the rat cerebral cortex. CPPG has weak effects at group I mGlu receptors[1].

• Product Name Alternative :

  (RS) -CPPG

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  MGluR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/cppg.html

• Purity :

  99.0

• Smiles :

  O=C(O)C(C1CC1)(N)C2=CC=C(P(O)(O)=O)C=C2

• Molecular Formula :

  C11H14NO5P

• Molecular Weight :

  271.21

• Precautions :

  H302

• References & Citations :

  [1]Toms NJ, et al. The effects of (RS) -alpha-cyclopropyl-4-phosphonophenylglycine ((RS) -CPPG), a potent and selective metabotropic glutamate receptor antagonist. Br J Pharmacol. 1996 Nov;119 (5) :851-4.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MGluR

• CAS Number :

  [183364-82-1]