CPPG

• Description:

  CPPG ((RS) -CPPG) is a potent group II/III mGlu receptors antagonist. CPPG exhibits some selectivity (approximately 20 fold) for group III (IC50=2.2 nM) over group II (IC50=46.2 nM) mGlu receptors in the rat cerebral cortex. CPPG has weak effects at group I mGlu receptors[1].

• Product Name Alternative:

  (RS) -CPPG

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  MGluR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/cppg.html

• Purity:

  99.0

• Smiles:

  O=C (O) C (C1CC1) (N) C2=CC=C (P (O) (O) =O) C=C2

• Molecular Formula:

  C11H14NO5P

• Molecular Weight:

  271.21

• Precautions:

  H302

• References & Citations:

  [1]Toms NJ, et al. The effects of (RS) -alpha-cyclopropyl-4-phosphonophenylglycine ((RS) -CPPG), a potent and selective metabotropic glutamate receptor antagonist. Br J Pharmacol. 1996 Nov;119 (5) :851-4.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  MGluR

• CAS Number:

  183364-82-1