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NLS-CPP

CAT: 0804-HY-P11207Size: 1 EachDry Ice: NoHazardous: No
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Description
NLS-CPP is a nuclear localization signal (NLS) -cell-penetrating peptide, which contains the NLS of OCT6. NLS-CPP facilitates nuclear delivery. NLS-CPP can be used for chronic inflammatory diseases s research, such as metabolic-dysfunction-associated steatohepatitis (MASH) and osteoarthritis (OA) [1].
CAS Number
1228086-59-6
Product Name Alternative
NLS-cell penetrating peptide
UNSPSC
12352209
Target
Others
Related Pathways
Others
Field of Research
Inflammation/Immunology
Smiles
O=C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H](C)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@H](O)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCC(O)=O)N
Molecular Formula
C63H115N25O21
Molecular Weight
1558.74
References & Citations
[1]Wang Y, et al. WSTF nuclear autophagy regulates chronic but not acute inflammation. Nature. 2025 Jul 2.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

Chemical Information

H-Glu-Glu-Glu-Ala-Ala-Gly-Arg-Lys-Arg-Lys-Lys-Arg-Thr-OH
CAS Number1228086-59-6
PubChem CID178203522
IUPAC Name(4S)-4-amino-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
Molecular FormulaC63H115N25O21
Molecular Weight1558.7
XLogP-19.7
Topological Polar Surface Area816
Hydrogen Bond Donor Count27
Hydrogen Bond Acceptor Count28
Rotatable Bond Count59
Heavy Atom Count109
Formal Charge0
Complexity3100
SMILES
C[C@H]([C@@H](C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)N)O
InChI
InChI=1S/C63H115N25O21/c1-32(78-50(98)33(2)79-52(100)42(20-23-46(93)94)87-58(106)43(21-24-47(95)96)81-51(99)35(67)19-22-45(91)92)49(97)77-31-44(90)80-36(16-10-28-74-61(68)69)53(101)82-37(13-4-7-25-64)55(103)85-40(17-11-29-75-62(70)71)57(105)84-38(14-5-8-26-65)54(102)83-39(15-6-9-27-66)56(104)86-41(18-12-30-76-63(72)73)59(107)88-48(34(3)89)60(108)109/h32-43,48,89H,4-31,64-67H2,1-3H3,(H,77,97)(H,78,98)(H,79,100)(H,80,90)(H,81,99)(H,82,101)(H,83,102)(H,84,105)(H,85,103)(H,86,104)(H,87,106)(H,88,107)(H,91,92)(H,93,94)(H,95,96)(H,108,109)(H4,68,69,74)(H4,70,71,75)(H4,72,73,76)/t32-,33-,34+,35-,36-,37-,38-,39-,40-,41-,42-,43-,48-/m0/s1
InChIKey
WZGAAZXIYNPJKT-IKWRVXSSSA-N
Chemical Structure
2D Structure
2D structure of H-Glu-Glu-Glu-Ala-Ala-Gly-Arg-Lys-Arg-Lys-Lys-Arg-Thr-OH
CAS: 1228086-59-6
CID: 178203522
Formula: C63H115N25O21
MW: 1558.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight1558.7
XLogP3-19.7
Hydrogen Bond Donor Count27
Hydrogen Bond Acceptor Count28
Rotatable Bond Count59
Exact Mass1557.86993578
Monoisotopic Mass1557.86993578
Topological Polar Surface Area816 Ų
Heavy Atom Count109
Formal Charge0
Complexity3100
Isotope Atom Count0
Defined Atom Stereocenter Count13
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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